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We are happy to report Summit facts updated on 13th September 2011:
222 Registered Participants from
33 Countries
34 Invited lectures
64 Unsolicited Scientific Contributions, accomodated in the final programme as:
Oral Presentations: 26
Posters: 39
Breath Analysis Summit overview
This summit is jointly organized by the International Association for Breath Research (IABR) and the Municipality of Parma. The Summit is organized to provide a forum to scientists, engineers, and clinicians to present their latest findings and to meet industry executives and entrepreneurs to discuss key trends, future directions, and technologies available for breath analysis. Relevant applications will include methods for non invasively diagnosing respiratory and non-respiratory diseases, assessing exposure to environmental pollutants, and addressing bioterrorism / security issues.
A major focus this year will be on nitric oxide, exhaled breath condensate, electronic nose, mass spectrometry, and newer sensor technologies. Medical applications range from asthma and other respiratory diseases to gastrointestinal disease, occupational diseases, critical care, and cancer.
Exhaled breath testing is becoming an increasingly important non-invasive diagnostic method that can be used in the evaluation of health and disease states. Potential advantages of breath tests over other conventional medical tests include their non-invasive nature, low cost, and safety. This is an area where the modern day advances in technology and engineering meet the ever expanding need in medicine for more sensitive, specific and non-invasive tests which makes this area a major front in the interface between medicine and engineering.
Proceedings will be published in the Journal of Breath Research.
Final Program
| Sunday, 11 September | Opening lecture | |
| 04.30PM | Registration | |
| 06.00PM | Opening lecture - P.J. Barnes: | I.1 Exhaled breath biomarkers |
| 07.00PM | Welcome Cocktail | |
| Monday, 12 September | Exhaled nitric oxide (NO) | |
| Chairs: | L. Fabbri, R. Dweik | |
| 09.00AM | L. Fabbri | I.2 Can biomarkers drive personalized medicine? |
| 09.30AM | S. Kharitonov | I.3 Spirituality, Religion, and Health, Efficacy of Prayer and its Assessment: New Area for Exhaled Biomarkers |
| 10.00AM | R. Dweik | I.4 Exhaled NO in asthma |
| 10.30AM | Coffee break | |
| 11.00AM | G. Piacentini | I.5 Measurement of Exhaled NO in Routine Practice |
| 11.30AM | C. Bucca | I.6 Exhaled NO in non pulmonary diseases |
| 12.00PM | M. Maniscalco | I.7 Exhaled nasal NO: what does it tell us? |
| 12.30PM | A.S. Modak | I.8 Why phenotype breath tests trump genotype tests to individualize therapy? |
| 01.00PM | Lunch | |
| Monday, 12 September | Exhaled breath condensate (EBC) | |
| Chairs | P.J. Barnes, I. Horvath | |
| 02.00PM | P. Rosias | I.9 Methodological aspects of EBC collection and analysis |
| 02.30PM | S. Loukides | I.10 EBC in asthma and COPD |
| 03.00PM | C. Gessner | I.11 EBC in lung cancer |
| 03.30PM | L. Ciaffoni | I.12 Laser-based Absorption Spectroscopy as a Technique for Rapid In-Line Analysis of Respired Gas Concentrations of Oxygen, Carbon Dioxide and Water Vapour |
| 04.00PM | J. Hunt | I.13 What does EBC pH tell us? |
| 04.30PM | E.Baraldi | I.14 Metabonomics of EBC |
| 05.00PM | I. Horvath | I.15 EBC: pearls and pitfalls |
| Monday, 12 September 2011 Conference Room A Selected oral presentations on Methodological aspects of breath analysis |
Chair: A. Amman, M. Hepton | |
| 05.30PM | M. Sawano, A. Shimouchi | O.1. A tracer analysis to demonstrate and quantify the redistribution of endogenous carbon monoxide from blood to tissue |
| 05.40PM | O. Beck | O.2. Developing exhaled breath as a matrice for drugs of abuse testing |
| 05.50PM | A. Aksenov, A. Gojova, W. Zhao, M. Schivo, C. Sandrock, N. J. Kenyon, R. Harper, C.E. Davis | O.3. Examining mammalian cell culture headspace volatile organic compounds for biomarkers of cellular changes |
| 06.00PM | J. Hunt | O.4. An inexpensive 5-minute assay system for breath aldehydes, with sensitivity below 100 ppb |
| 06.10PM | J. Izquierdo-Garcia, G. Peces-Barba, J. Ruiz-Cabello | O.5. Is the NMR-based metabolomic analysis of Exhaled Breath Condensate accurate? |
| 06.20PM | T. Matsusaki, Hi. Morimatsu, J. Kosaka, J. Matsumi, H. Shimizu, T. Takahashi | O.6. Increase in Exhaled CO Concentration in Adult Living Donor Liver Transplantation |
| Conference Room B Selected oral presentations on Clinical aspects of exhaled breath analysis |
Chair: E. Baraldi, H. Wirtz | |
| 05.30PM | M. Hogman, P. Merilainen | O.7. Flow dependence of the flow independent NO parameters |
| 05.40PM | U. Tisch, R. Ionescu, R. Bassal, M. Nakhleh, N. Axelrod, D. Robertman, Y. Tessler, A. Marmur, I. Schlesinger, J. Aharon-Peretz, H. Haick | O.8. The "Breath-Prints" of Parkinson's Disease and Alzheimer's Disease |
| 05.50PM | D. Fuchs, H. Jamnig, P. Heininger, M. Klieber, S. Schroecksnadel, M. Fiegl, M. Hackl, H. Denz , A. Amann | O.9. Decline of exhaled isoprene in lung cancer correlates with immune activation |
| 06.00PM | KDG van de Kant, JJBN van Berkel, Q Jobsis, V Lima Passos, EMM Klaassen, L van der Sande, CP van Schayck, JC de Jongste, FJ van Schooten, E Dompeling, JW Dallinga. | O.10. Exhaled breath profiling in the diagnosis of wheezy preschool children |
| 06.10PM | C. Sachs-Olsen, M. Sanak, A.M. Lang, A. Gielicz, P. Mowinckel, K. Cecilie, L. Carlsen, K. Carlsen, A. Szczeklik | O.11. Eoxins - A new inflammatory pathway in childhood asthma |
| 06.20PM | A. Fell, H. Noto, M. Skogstad, K.Nordby, W. Eduard, M. Veel Svendsen, R. Ovstebo, A. Siebke Troseid, J. Kongerud | O.12. A cross-shift study of lung function, exhaled nitric oxide, and inflammatory markers in blood in Norwegian cement production workers |
| 06.30PM | DK Milton, MP Fabian, J McDevitt | O.13. Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks. |
| Tuesday, 13 September | Exhaled volatile organic compounds (VOCs) in lung diseases | |
| Chairs | D. Olivieri, A. Amann | |
| 09.00AM | T. Risby | I.16 Methodological aspects of VOC collection |
| 09.30AM | A. Amann | I.17 Research Fields Involving Volatile Compounds: Achievements and Challenges |
| 10.00AM | Miekisch W | I.18 Data processing in breath analysis - From reading the runes to valid science |
| 10.30AM | Coffee break | |
| 11.00AM | FJ Van Schooten | I.19 Metabolomics of Exhaled VOCs by GC-MS-TOF in Inflammatory Lung Diseases |
| 11.30AM | P.Mazzone | I.20 Exhaled VOCs in lung cancer |
| 12.00PM | M. Rosenberg | I.21 Microorganisms and Breath Odors |
| 12.30PM | J.I. Baumbach | I.22 Ion mobility spectrometers in point of care, intensive care and systems biology |
| 01.00PM | Lunch | |
| Tuesday, 13 September | Breath tests in different clinical conditions | |
| Chairs | I.23 T. Risby, J.I. Baumbach | |
| 02.00PM | M. Phillips | I.24 Breath Tests in Different Clinical Conditions |
| 02.30PM | T.Popov | I.25 Exhaled breath temperature and inflammation |
| 03.00PM | JK Schubert | I.26 Breath Analysis for Monitoring of inflammatory and metabolic processes |
| 03.30PM | W. Denzer | I.27 Determination of breath methane levels using Cavity Enhanced Absorption Spectroscopy - a feasibility study |
| 04.00PM | PR Galassetti | I.28 Exhaled breath in diabetes |
| 04.30PM | JA Vogt | I.29 13CO2 breath tests using infra red spectroscopy |
| 05.00PM | J.Dallinga | Inflammatory Bowel Diseases: Diagnosis and Monitoring |
| Tuesday 13 September2011 Conference Room A Selected oral presentations on Methodological aspects of exhaled breath analysis |
Chair: J. Pleil, W. Miekish | |
| 05.30PM | M. Syhre, J. Gerhold, H. Wirt | O.14. Cutting down to the essentials - the urgent need for validation of electronic nose systems in the quest for early lung cancer detection via breath |
| 05.40PM | B. Grabowska-Polanowska, J. Faber, I. Sliwka | O.15. The trace analysis of amines in gaseous samples using GC/MS and chosen preconcentration methods |
| 05.50PM | J. Beauchamp | O.16. Confounding variables in breath analysis - you air what you eat! |
| 06.00PM | F. Hoffmeyer, M. Raulf-Heimsoth, T. WeiB, M. Lehnert, B. Kendzia, V. Harth, J. Henry B. Pesch, T. Bruning | O.17. Relation between EBC biomarkers and internal exposure to metals from gas metal arc welding |
| 06.10PM | W Filipiak, A. Sponring, A. Filipiak, C. Ager, A. Bajtarevic, J. Tropair, A. Amann | O.18. Analysis of volatile organic compounds (VOCs) by TD-GC-MS: possible application for the selection of cancer-related metabolites? |
| 06.20PM | T.Ligor, E. Trawinska, K. Cieslinski, B.Buszewski | O.19. Hyphenated techniques for identification of VOCs in breath |
| 06.30PM | V.L. Vaks, E.G. Domracheva, A.V. Maslennikova, S.I. Pripolzin, E.A. Sobakinskaya, M.B. Chernyaeva | O.20. The Terahertz Nonstationary Spectroscopy for Exhaled Breath Analysis |
| Conference Room B Selected oral presentations on Clinical aspects of exhaled breath analysis |
Chair: R. Dweik, FJ. Van Scooten | |
| 05.30PM | Y. Joseph, I. Raible, M. Sarpasan, G. Nelles, N. Krasteva | O.21 Chemiresistive Nanocomposite Sensors and Electonic Nose for Breath Analaysis Applications |
| 05.40PM | J. Herbig, K. Winkler, I. Kohl A. Hansel | O.22 Monitoring Metabolic Processes using Real-Time Breath Analysis with PTR-MS |
| 05.50PM | G. Vidal-de-Miguel, A. Herrero, G. Bailador, E. Criado, F. Zambrana, C. Sanchez, E. Casado | O.23 Towards an Online Breath Cancer Diagnostic Tool |
| 06.00PM | F. N. Schleich, R. Asandei, M. Manise, J. Sele, C. Graas, R. Louis | O.24 Are FENO indices useful diagnostic tools in suspected asthma? |
| 06.10PM | V. Ruzsanyi, A. Amann | O.25 Ion mobility spectrometry: a portable tool for fast analysis of exhaled breath |
| 06.20PM | M.P. Hlastala, J.C. Anderson | O.26 Exchange of Highly Soluble Gases by the Lungs |
| Wednesday, 14 September | ||
| 08.30AM | Discussant: DK Milton | Poster Discussion |
| Breath Biomarkers in Environmental Health | ||
| Chairs | A. Mutti, J. Pleil | |
| 09.30AM | J. Pleil | I.30 Breath Biomarkers in Environmental Health Science: Exploring Patterns in the Human Exposome |
| 10.30AM | M. Goldoni | I.31 Metallic elements in exhaled breath condensate |
| 10.30AM | A.C. Olin | I.32 Exhaled particles for sampling non-volatiles in breath |
| 11.00AM | Coffee break | |
| 11.15AM | J. King | I.33 Real-time measurements of exhaled breath |
| 11.45AM | M. Luisetti and P. Iadarola | I.34 Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients |
| 12.15PM | A. Amann | Closing remarks |
Posters
A. Biomarkers in Exhaled Breath Condesate
A.1 Determination of Anions in Exhaled Breath Condensate by Ionic Chromatography. G. Folesani, M. Corradi, P. Gergelova and A. Mutti
A.2 Exhaled pH in asthmatic children with grass allergy. C. Zinelli, C. Povesi Dascola, L. Rinaldi, M. Corradi, C. Caffarelli
A.3 NMR metabolomics of Exhaled Breath Condensate identify and delineate asthma. A. Sinha.
A.4 Exhaled breath markers in asthmatic and control children. G. Koppen, K. Bloemen, R. Van Den Heuvel, V. Nelen, E. Witters, K. Desager, G. Schoeters
A.5 EBC pH in Croatian green-mill workers. A. Ljubicic Calusic, V.M. Varnai, J. Macan
A.6 Early molecular diagnosis of lung cancer: a method to rule out the disease. D. Poli, M. Goldoni, M. Corradi , O. Acampa, P.Mozzoni, S.Pinelli, F.Sabbadini, P. Carbognani, E.Internullo, A.Casalini, A.Mutti
A.7 Oxidative stress and airway inflammation in workers exposed to crystalline silica and in patient with silicosis assessed by lung function tests and exhaled breath condensate. Murgia N, Montuschi P, Gambelunghe A, Dell’Omo M, Ciabattoni G, Abbritti G, Muzi G.
A.8 IgG Anchored on Chitosan Coated Magnetic Nanoparticles Separation combined with LC-MS: A Method for Monitoring Genetic Oxidative Stress Biomarkers. P. Kacer, K. Syslovaa, M. Kuzma, S. Vlckova, J. Lebedova, Z. Fenclova and D. Pelclova
B. Nitric oxide and carbon monoxide in exhaled breath
B.1 Effect of axial back-diffusion on exhaled NO analysis on interpreting results measured at flows from 50 to 400 mL/s. M. Hogman & P. Merilainen
B.2 Comparisons of correction for axial back diffusion of NO. M. Hogman & P. Merilainen
B.3 Fractional exhaled nitric oxide in patients with type 2 diabetes mellitus and its relationship with Cardiovascular risk markers in Saudi adults. S. S. Habib
B.4 Fractional exhaled nitric oxide and its Relationship with Body-composition and Fitness Scoring in Healthy Adults. S. S. Habib
B.5 Quantum cascade-based sensor for FeNO measurements at multiple flows rates. J. Mandon, P.J.F.M. Merkus, F.J.M. Harren and S.M. Cristescu
B.6 Effect of ramp bicycle exercise on carbon monoxide exhalation in smokers and non-smokers. Y. Yasuda, T. Ito, M. Miyamura and M. Niwayama
B.7 The meaning of chlorinated compounds in the exhaled breath of pulmonary disease carriers. S. Gramacho, A.A.C.C. Pais, A.M. d'Rocha Gonsalves, F. Gamboa, C.M.S. Robalo Cordeiro, M. Pineiro
C. Exhaled volatile organic compounds
C.1 Nanocomposite sensors and electronic nose for assessment of volatile anesthetics - towards anesthesia monitoring via exhaled breath analysis. N. Krasteva, I. Raible, Y. Joseph, M. Sarpasan, G. Nelles
C.2 Discrimination of lung cancer and COPD patients using breath analysis via E-Nose. Raible, Y. Joseph, M. Sarpasan, G. Nelles, N.K. Mona Syhre, J. Gerhold, H. Wirtz
C.3 Prospecting for volatile organic compounds in respiratory diseases. C. Guallar-Hoyas, I. Wilson, C.L.Paul Thomas
C.4 Exhaled VOC as new markers for Colorectal Cancer. D.F. Altomare, G. de Gennaro, M. Di Lena, G. Gigante, S. Giuratrabocchetta, M. Lemma, S. Pistillo, F. Porcelli, G. Stallone, L. Trizio, M. Tutino
C.5 Cross-validation of two electronic nose systems in the quest for early lung cancer detection via breath. H. Wirtz, M. Syhre, J. Gerhold, S. Hammerschmidt
C.6 Hydrogen cyanide in breath and emitted from skin - an in-depth study using cavity ring-down spectroscopy. M. Metsala, F.M. Schmidt, O. Vaittinen, M. Skytta, L. Halonen
C.7 Diesel exposure assessment by analysis of hydrocarbons in the exhaled breath of submariners. G. DeNola, P. J. Hanhela, K Lazarus, T.H. Gan and W. Mazurek
C.8 Acetone in the human breath by portable Si:WO3 gas sensors. M. Righettoni, A. Tricoli, S. Gass, A. Schmid, A. Amann and S.E. Pratsinis
C.9 The gas micropreconcentrator structures for low level breath acetone concentration detection. A. Rydosz, W. Maziarz, T. Pisarkiewicz, K. Doma?ski, P. Grabiec
C.10 GC-TOF-MS as a tool for trace level VOC analysis for the measurement and identification of potential bio-markers of disease in human breath. S. Smith
C.11 Real time metabolization dynamics measured in exhaled breath as a tool for liver assessment. K. Heyne, A. Helmke, T. Rubin, T. von Haimberger, M. Stockmann
D. Methodological aspects of exhaled breath collection and analysis
D.1 The effect of psychological stress on human breath profiles. M. A. Turner, P. Patel, C. Guallar-Hoyas, H.J. Reid, I.D. Wilson, C.L. P. Thomas
D.2 A Study of the Volatiles from Urine and Their Potential for the Diagnoses of Prostate Cancer, Bladder Cancer and Urinary Tract Infections. H. Al-Kateb, B. de Lacy Costello, R.J. Ewen, T. Khalid, Ch. Probert, N. Ratcliffe and P. White
D.3 Pharmacokinetic models of post-operative elimination of sevoflurane anesthetic and hexafluoroisopropanol metabolite as measured in exhaled breath. S. Ghimenti, J. Pleil, M. Onor, C. Comite, N. Catania, M.G. Trivella, R .Fuoco, F. Di Francesco
D.4 Comparison of a breath analysing system based upon Ion Mobility Spectrometry (IMS) to a Differential Ion Mobility Spectrometry (DMS) in equine species. C.C. Klein, G. Becher, R. Purkart, W. Schueler, S. Wietstock, M. Hoffmann
D.5 Ion Mobility Spectrometry - A Detection Method for specific Biomarkers from Exhalate for Detection of Non-airway-Diseases. G. Becher, A. Hillmann, R. Purkhart, M. Graupner, R. Graupner
D.6 Automatic classification of breath samples measured with ion mobility spectrometry (DMS/IMS). R. Purkhart, G. Becher, A. Hillmann, R. Graupner, W. Schuler
D.7 Methodology for the Determination of the Detection Limits for the Proton Transfer Reaction Mass Spectrometer Measurements. V. Witkovsky and G. Wimmer
D.8 Automated controlled sampling on packed micro extraction needles (NTD). D. Hein, L. Rosner, P. Trefz, W. Miekisch
D.9 A new device based on the exhaled-CO2 signal to collect the alveolar fraction of exhaled breath condensate. M. Goldoni, M. Corradi, P. Mozzoni, G. Folesani, R. Andreoli, A. Mutti
D.10 Exhaled VOCs: a comparison between different portions of exhaled air. D. Poli, M. CorradI, M. Goldoni, O. Acampa, R. Alinovi, A. Mutti
D.11 Reduced breath condensate pH in asymptomatic children with prior wheezing as risk factor for asthma. C.Vogelberg, F. Pessler, M. Akmatov, J.Li, U.Range, M.von Jagwitz